PDM: Metabolic Syndrome (2013)
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Assessment
In adults with metabolic syndrome, what is the impact of weight loss (over at least a three-month period) on glycemic-related outcomes (such as fasting blood glucose, random blood glucose, two-hour post-prandial blood glucose, A1C)?
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Conclusion
Most studies reported no significant impact of weight loss on fasting glucose levels in adults with metabolic syndrome. However, of two intervention studies reporting A1C values, both demonstrated that weight loss significantly reduced A1C by 0.12% to 0.3%.
Additional longer-term intervention studies are needed to ascertain an effect of weight loss on glycemic-related outcomes in adults with metabolic syndrome with or without meeting the metabolic syndrome criteria for impaired glucose tolerance and impaired fasting glucose.
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Grade: II
- Grade I means there is Good/Strong evidence supporting the statement;
- Grade II is Fair;
- Grade III is Limited/Weak;
- Grade IV is Expert Opinion Only;
- Grade V is Not Assignable.
- High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
- Moderate (B) means we are moderately confident in the effect estimate;
- Low (C) means our confidence in the effect estimate is limited;
- Very Low (D) means we have very little confidence in the effect estimate.
- Ungraded means a grade is not assignable.
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Evidence Summary: In adults with metabolic syndrome, what is the impact of weight loss (over at least a three-month period) on glycemic-related outcomes (such as fasting blood glucose, random blood glucose, two-hour post-prandial blood glucose, A1C)?
- Detail
- Quality Rating Summary
For a summary of the Quality Rating results, click here.
- Worksheets
- Aizawa K, Shoemaker JK, Overend TJ, Petrella RJ. Effects of lifestyle modification on central artery stiffness in metabolic syndrome subjects with pre-hypertension and/or pre-diabetes. Diabetes Res Clin Pract. 2009; 83: 249-256.
- Bihan H, Takbou K, Cohen R, Michault A, Boitou F, Reach G, Le Clesiau H. Impact of short-duration lifestyle intervention in collaboration with general practitioners in patients with the metabolic syndrome. Diabetes & Metabolism. 2009; 35: 185-191.
- Busnello FM, Bodanese LC, Pellanda LC, Santos ZE. Nutritional intervention and the impact on adherence to treatment in patients with metabolic syndrome. Arq Bras Cardiol. 2011; 97(3): 217-224.
- Chan DC, Watts GF, Ng TWK, Yamashita S, Barrett, PHR. Effect of weight loss on markers of triglyceride-rich lipoprotein metabolism in the metabolic syndrome. Eur J Clin Invest. 2008; 38 (10): 743-751.
- Christian JG, Byers TE, Christian KK, Goldstein MG, Bock BC, Prioreschi B, Bessesen DH. A computer support program that helps clinicians provide patients with metabolic syndrome tailored counseling to promote weight loss. J Am Diet Assoc. 2011; 111(1): 75-83.
- Kim MK, Tanaka K, Kim MJ, Matsuo T, Ajisaka R. Exercise training-induced changes in heart rate recovery in obese men with metabolic syndrome. Metab Syndr Relat Disord. 2009 Oct; 7 (5): 469-476.
- Lee K, Lee J, Bae WK, Choi JK, Kim HJ, Cho B. Efficacy of low-calorie, partial meal replacement diet plans on weight and abdominal fat in obese subjects with metabolic syndrome: A double-blind, randomized controlled trial of two diet plans - one high in protein and one nutritionally balanced. Int J Clin Pract. 2009; 63(2): 195-201.
- Mujica V, Urzua A, Leiva E, Diaz N, Moore-Carrasco R, Vasquez M, Rojas E, Icaza G, Toro C, Orrego R, Palomo I. Intervention with education and exercise reverses the metabolic syndrome in adults. J Am Soc Hypertens. 2010; 4(3): 148-153.
- Munakata M, Honma H, Akasi M, Araki T, Kawamura T, Kubota M, Yokokawa T, Numata Y, Toyonaga T, J-STOP-MetS Study Group. Repeated counselling improves the antidiabetic effects of limited individualized lifestyle guidance in metabolic syndrome: J-STOP-METS final results. Hypertens Res. 2011; 34 (5): 612-616.
- Ng TW, Chan DC, Barrett PH, Watts GF. Effect of weight loss on HDL-apoA-II kinetics in the metabolic syndrome. Clin Sci (Lond). 2009; 118(1): 79-85.
- Oh EG, Bang SY, Hyun SS, Kim SH, Chu SH, Jeon JY, Im JA, Lee MK, Lee JE. Effects of a six-month lifestyle modification intervention on the cardiometabolic risk factors and health-related qualities of life in women with metabolic syndrome. Metabolism. 2010; 59(7): 1,035-1,043.
- Straznicky NE, Grima MT, Lambert EA, Eikelis N, Dawood T, Lambert GW, Nestel PJ, Masuo K, Sari CI, Chopra R, Mariani JA, Schlaich MP. Exercise augments weight loss induced improvement in renal function in obese metabolic syndrome individuals. J Hypertens. 2011; 29(3): 553-564.
- Straznicky NE, Lambert EA, Nestel PJ, McGrane MT, Dawood T, Schlaich MP, Masuo K, Eikelis N, de Courten B, Mariani JA, Esler MD, Socratous F, Chopra R, Sari CI, Paul E, Lambert GW. Sympathetic neural adaptation to hypocaloric diet with or without exercise training in obese metabolic syndrome subjects. Diabetes. 2010; 59(1): 71-79.
- Straznicky NE, Lambert EA, Grima MT, Eikelis N, Nestel PJ, Dawood T, Schlaich MP, Masuo K, Chopra R, Sari CI, Dixon JB, Tilbrook AJ, Lambert GW. The effect of dietary weight loss with or without exercise training on liver enzymes in obese metabolic syndrome subjects. Diabetes Obes Metab. 2012; 14(2): 139-148.
- Yassine HN, Marchetti CM, Krishnan RK, Vrobel TR, Gonzalez F, Kirwan JP. Effects on exercise and caloric restriction on insulin resistance and cardiometabolic risk factors in older obese adults: A randomized clinical trial. J Gerontol A Biol Sci Med Sci. 2009; 64: 90-95.
- Detail
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Search Plan and Results: PDM: Weight Loss and Metabolic Syndrome 2012
In adults with metabolic syndrome, what is the impact of weight loss (over at least a three-month period) on lipid outcomes (TG, HDL)?-
Conclusion
The majority of research reported that a weight loss ranging from 1.1kg to 13kg significantly reduced triglyceride levels by 20mg to 132mg per dL (0.23mmol to 1.5mmol per L) in adults with metabolic syndrome.
However, most studies reported no significant impact of weight loss on HDL-cholesterol levels in adults with metabolic syndrome.
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Grade: I
- Grade I means there is Good/Strong evidence supporting the statement;
- Grade II is Fair;
- Grade III is Limited/Weak;
- Grade IV is Expert Opinion Only;
- Grade V is Not Assignable.
- High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
- Moderate (B) means we are moderately confident in the effect estimate;
- Low (C) means our confidence in the effect estimate is limited;
- Very Low (D) means we have very little confidence in the effect estimate.
- Ungraded means a grade is not assignable.
-
Evidence Summary: In adults with metabolic syndrome, what is the impact of weight loss (over at least a 3-month period) on lipid outcomes (TG, HDL)?
- Detail
- Quality Rating Summary
For a summary of the Quality Rating results, click here.
- Worksheets
- Aizawa K, Shoemaker JK, Overend TJ, Petrella RJ. Effects of lifestyle modification on central artery stiffness in metabolic syndrome subjects with pre-hypertension and/or pre-diabetes. Diabetes Res Clin Pract. 2009; 83: 249-256.
- Al Sarraj T, Saadi H, Volek JS, Fernandez ML. Carbohydrate restriction favorably alters lipoprotein metabolism in Emirati subjects classified with the metabolic syndrome. Nutr Metab Cardiovasc Dis 2010;20(10):720-6.
- Bihan H, Takbou K, Cohen R, Michault A, Boitou F, Reach G, Le Clesiau H. Impact of short-duration lifestyle intervention in collaboration with general practitioners in patients with the metabolic syndrome. Diabetes & Metabolism. 2009; 35: 185-191.
- Busnello FM, Bodanese LC, Pellanda LC, Santos ZE. Nutritional intervention and the impact on adherence to treatment in patients with metabolic syndrome. Arq Bras Cardiol. 2011; 97(3): 217-224.
- Chan DC, Watts GF, Ng TWK, Yamashita S, Barrett, PHR. Effect of weight loss on markers of triglyceride-rich lipoprotein metabolism in the metabolic syndrome. Eur J Clin Invest. 2008; 38 (10): 743-751.
- Christian JG, Byers TE, Christian KK, Goldstein MG, Bock BC, Prioreschi B, Bessesen DH. A computer support program that helps clinicians provide patients with metabolic syndrome tailored counseling to promote weight loss. J Am Diet Assoc. 2011; 111(1): 75-83.
- Cicero AF, Derosa G, Bove M, Di Gregori V, Gaddi AV, Borghi C. Effect of a sequential training programme on inflammatory, prothrombotic and vascular remodelling biomarkers in hypertensive overweight patients with or without metabolic syndrome. Eur J Cardiovasc Prev Rehabil. 2009; 16(6): 698-704.
- Kim MK, Tanaka K, Kim MJ, Matsuo T, Ajisaka R. Exercise training-induced changes in heart rate recovery in obese men with metabolic syndrome. Metab Syndr Relat Disord. 2009 Oct; 7 (5): 469-476.
- Lee K, Lee J, Bae WK, Choi JK, Kim HJ, Cho B. Efficacy of low-calorie, partial meal replacement diet plans on weight and abdominal fat in obese subjects with metabolic syndrome: A double-blind, randomized controlled trial of two diet plans - one high in protein and one nutritionally balanced. Int J Clin Pract. 2009; 63(2): 195-201.
- Mujica V, Urzua A, Leiva E, Diaz N, Moore-Carrasco R, Vasquez M, Rojas E, Icaza G, Toro C, Orrego R, Palomo I. Intervention with education and exercise reverses the metabolic syndrome in adults. J Am Soc Hypertens. 2010; 4(3): 148-153.
- Munakata M, Honma H, Akasi M, Araki T, Kawamura T, Kubota M, Yokokawa T, Numata Y, Toyonaga T, J-STOP-MetS Study Group. Repeated counselling improves the antidiabetic effects of limited individualized lifestyle guidance in metabolic syndrome: J-STOP-METS final results. Hypertens Res. 2011; 34 (5): 612-616.
- Ng TW, Chan DC, Barrett PH, Watts GF. Effect of weight loss on HDL-apoA-II kinetics in the metabolic syndrome. Clin Sci (Lond). 2009; 118(1): 79-85.
- Oh EG, Bang SY, Hyun SS, Kim SH, Chu SH, Jeon JY, Im JA, Lee MK, Lee JE. Effects of a six-month lifestyle modification intervention on the cardiometabolic risk factors and health-related qualities of life in women with metabolic syndrome. Metabolism. 2010; 59(7): 1,035-1,043.
- Straznicky NE, Grima MT, Lambert EA, Eikelis N, Dawood T, Lambert GW, Nestel PJ, Masuo K, Sari CI, Chopra R, Mariani JA, Schlaich MP. Exercise augments weight loss induced improvement in renal function in obese metabolic syndrome individuals. J Hypertens. 2011; 29(3): 553-564.
- Straznicky NE, Lambert EA, Nestel PJ, McGrane MT, Dawood T, Schlaich MP, Masuo K, Eikelis N, de Courten B, Mariani JA, Esler MD, Socratous F, Chopra R, Sari CI, Paul E, Lambert GW. Sympathetic neural adaptation to hypocaloric diet with or without exercise training in obese metabolic syndrome subjects. Diabetes. 2010; 59(1): 71-79.
- Straznicky NE, Lambert EA, Grima MT, Eikelis N, Nestel PJ, Dawood T, Schlaich MP, Masuo K, Chopra R, Sari CI, Dixon JB, Tilbrook AJ, Lambert GW. The effect of dietary weight loss with or without exercise training on liver enzymes in obese metabolic syndrome subjects. Diabetes Obes Metab. 2012; 14(2): 139-148.
- Yassine HN, Marchetti CM, Krishnan RK, Vrobel TR, Gonzalez F, Kirwan JP. Effects on exercise and caloric restriction on insulin resistance and cardiometabolic risk factors in older obese adults: A randomized clinical trial. J Gerontol A Biol Sci Med Sci. 2009; 64: 90-95.
- Detail
-
Search Plan and Results: PDM: Weight Loss and Metabolic Syndrome 2012
In adults with metabolic syndrome, what is the impact of weight loss (over at least a three-month period) on anthropometric outcomes (WC, WHR)?-
Conclusion
Research reports that a weight loss ranging from 1.1kg to 13kg significantly reduced waist circumference by 1.5 to 11cm in adults with metabolic syndrome.
However, most studies reported no significant impact of weight loss on waist-to-hip ratio in adults with metabolic syndrome.
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Grade: I
- Grade I means there is Good/Strong evidence supporting the statement;
- Grade II is Fair;
- Grade III is Limited/Weak;
- Grade IV is Expert Opinion Only;
- Grade V is Not Assignable.
- High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
- Moderate (B) means we are moderately confident in the effect estimate;
- Low (C) means our confidence in the effect estimate is limited;
- Very Low (D) means we have very little confidence in the effect estimate.
- Ungraded means a grade is not assignable.
-
Evidence Summary: In adults with metabolic syndrome, what is the impact of weight loss (over at least a three-month period) on anthropometric outcomes (WC, WHR)?
- Detail
- Quality Rating Summary
For a summary of the Quality Rating results, click here.
- Worksheets
- Aizawa K, Shoemaker JK, Overend TJ, Petrella RJ. Effects of lifestyle modification on central artery stiffness in metabolic syndrome subjects with pre-hypertension and/or pre-diabetes. Diabetes Res Clin Pract. 2009; 83: 249-256.
- Bihan H, Takbou K, Cohen R, Michault A, Boitou F, Reach G, Le Clesiau H. Impact of short-duration lifestyle intervention in collaboration with general practitioners in patients with the metabolic syndrome. Diabetes & Metabolism. 2009; 35: 185-191.
- Busnello FM, Bodanese LC, Pellanda LC, Santos ZE. Nutritional intervention and the impact on adherence to treatment in patients with metabolic syndrome. Arq Bras Cardiol. 2011; 97(3): 217-224.
- Chan DC, Watts GF, Ng TWK, Yamashita S, Barrett, PHR. Effect of weight loss on markers of triglyceride-rich lipoprotein metabolism in the metabolic syndrome. Eur J Clin Invest. 2008; 38 (10): 743-751.
- Christian JG, Byers TE, Christian KK, Goldstein MG, Bock BC, Prioreschi B, Bessesen DH. A computer support program that helps clinicians provide patients with metabolic syndrome tailored counseling to promote weight loss. J Am Diet Assoc. 2011; 111(1): 75-83.
- Kim MK, Tanaka K, Kim MJ, Matsuo T, Ajisaka R. Exercise training-induced changes in heart rate recovery in obese men with metabolic syndrome. Metab Syndr Relat Disord. 2009 Oct; 7 (5): 469-476.
- Klemsdal TO, Holme I, Nerland H, Pedersen TR, Tonstad S. Effects of a low glycemic load diet vs. a low-fat diet in subjects with and without the metabolic syndrome. Nutr Metab Cardiovasc Dis. 2010; 20 (3): 195-201.
- Lee K, Lee J, Bae WK, Choi JK, Kim HJ, Cho B. Efficacy of low-calorie, partial meal replacement diet plans on weight and abdominal fat in obese subjects with metabolic syndrome: A double-blind, randomized controlled trial of two diet plans - one high in protein and one nutritionally balanced. Int J Clin Pract. 2009; 63(2): 195-201.
- Mujica V, Urzua A, Leiva E, Diaz N, Moore-Carrasco R, Vasquez M, Rojas E, Icaza G, Toro C, Orrego R, Palomo I. Intervention with education and exercise reverses the metabolic syndrome in adults. J Am Soc Hypertens. 2010; 4(3): 148-153.
- Munakata M, Honma H, Akasi M, Araki T, Kawamura T, Kubota M, Yokokawa T, Numata Y, Toyonaga T, J-STOP-MetS Study Group. Repeated counselling improves the antidiabetic effects of limited individualized lifestyle guidance in metabolic syndrome: J-STOP-METS final results. Hypertens Res. 2011; 34 (5): 612-616.
- Ng TW, Chan DC, Barrett PH, Watts GF. Effect of weight loss on HDL-apoA-II kinetics in the metabolic syndrome. Clin Sci (Lond). 2009; 118(1): 79-85.
- Oh EG, Bang SY, Hyun SS, Kim SH, Chu SH, Jeon JY, Im JA, Lee MK, Lee JE. Effects of a six-month lifestyle modification intervention on the cardiometabolic risk factors and health-related qualities of life in women with metabolic syndrome. Metabolism. 2010; 59(7): 1,035-1,043.
- Seligman BG, Polanczyk CA, Santos AS, Foppa M, Junges M, Bonzanini L, Nicolaidis G, Carney S, Lopes AL, Sehl P, Duncan BB, Clausell N. Intensive practical lifestyle intervention improves endothelial function in metabolic syndrome independent of weight loss: A randomized controlled trial. Metabolism. 2011; 60(12): 1,736-1,740.
- Straznicky NE, Grima MT, Lambert EA, Eikelis N, Dawood T, Lambert GW, Nestel PJ, Masuo K, Sari CI, Chopra R, Mariani JA, Schlaich MP. Exercise augments weight loss induced improvement in renal function in obese metabolic syndrome individuals. J Hypertens. 2011; 29(3): 553-564.
- Straznicky NE, Lambert EA, Nestel PJ, McGrane MT, Dawood T, Schlaich MP, Masuo K, Eikelis N, de Courten B, Mariani JA, Esler MD, Socratous F, Chopra R, Sari CI, Paul E, Lambert GW. Sympathetic neural adaptation to hypocaloric diet with or without exercise training in obese metabolic syndrome subjects. Diabetes. 2010; 59(1): 71-79.
- Straznicky NE, Lambert EA, Grima MT, Eikelis N, Nestel PJ, Dawood T, Schlaich MP, Masuo K, Chopra R, Sari CI, Dixon JB, Tilbrook AJ, Lambert GW. The effect of dietary weight loss with or without exercise training on liver enzymes in obese metabolic syndrome subjects. Diabetes Obes Metab. 2012; 14(2): 139-148.
- Yassine HN, Marchetti CM, Krishnan RK, Vrobel TR, Gonzalez F, Kirwan JP. Effects on exercise and caloric restriction on insulin resistance and cardiometabolic risk factors in older obese adults: A randomized clinical trial. J Gerontol A Biol Sci Med Sci. 2009; 64: 90-95.
- Detail
-
Search Plan and Results: PDM: Weight Loss and Metabolic Syndrome 2012
In adults with metabolic syndrome, what is the impact of weight loss (over at least a three-month period) on blood pressure?-
Conclusion
Most studies reported that a weight loss ranging from 1.1kg to 8.4kg significantly reduced systolic blood pressure by 4.9mm Hg to 10mm Hg in adults with metabolic syndrome.
However, the research regarding weight loss reports mixed results on diastolic blood pressure in adults with metabolic syndrome.
Additional longer-term intervention studies are needed to ascertain an effect of weight loss on blood pressure in adults with metabolic syndrome with or without meeting the metabolic syndrome criteria for blood pressure.
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Grade: II
- Grade I means there is Good/Strong evidence supporting the statement;
- Grade II is Fair;
- Grade III is Limited/Weak;
- Grade IV is Expert Opinion Only;
- Grade V is Not Assignable.
- High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
- Moderate (B) means we are moderately confident in the effect estimate;
- Low (C) means our confidence in the effect estimate is limited;
- Very Low (D) means we have very little confidence in the effect estimate.
- Ungraded means a grade is not assignable.
-
Evidence Summary: In adults with metabolic syndrome, what is the impact of weight loss (over at least a 3-month period) on blood pressure?
- Detail
- Quality Rating Summary
For a summary of the Quality Rating results, click here.
- Worksheets
- Aizawa K, Shoemaker JK, Overend TJ, Petrella RJ. Effects of lifestyle modification on central artery stiffness in metabolic syndrome subjects with pre-hypertension and/or pre-diabetes. Diabetes Res Clin Pract. 2009; 83: 249-256.
- Bihan H, Takbou K, Cohen R, Michault A, Boitou F, Reach G, Le Clesiau H. Impact of short-duration lifestyle intervention in collaboration with general practitioners in patients with the metabolic syndrome. Diabetes & Metabolism. 2009; 35: 185-191.
- Chan DC, Watts GF, Ng TWK, Yamashita S, Barrett, PHR. Effect of weight loss on markers of triglyceride-rich lipoprotein metabolism in the metabolic syndrome. Eur J Clin Invest. 2008; 38 (10): 743-751.
- Christian JG, Byers TE, Christian KK, Goldstein MG, Bock BC, Prioreschi B, Bessesen DH. A computer support program that helps clinicians provide patients with metabolic syndrome tailored counseling to promote weight loss. J Am Diet Assoc. 2011; 111(1): 75-83.
- Kim MK, Tanaka K, Kim MJ, Matsuo T, Ajisaka R. Exercise training-induced changes in heart rate recovery in obese men with metabolic syndrome. Metab Syndr Relat Disord. 2009 Oct; 7 (5): 469-476.
- Mujica V, Urzua A, Leiva E, Diaz N, Moore-Carrasco R, Vasquez M, Rojas E, Icaza G, Toro C, Orrego R, Palomo I. Intervention with education and exercise reverses the metabolic syndrome in adults. J Am Soc Hypertens. 2010; 4(3): 148-153.
- Munakata M, Honma H, Akasi M, Araki T, Kawamura T, Kubota M, Yokokawa T, Numata Y, Toyonaga T, J-STOP-MetS Study Group. Repeated counselling improves the antidiabetic effects of limited individualized lifestyle guidance in metabolic syndrome: J-STOP-METS final results. Hypertens Res. 2011; 34 (5): 612-616.
- Oh EG, Bang SY, Hyun SS, Kim SH, Chu SH, Jeon JY, Im JA, Lee MK, Lee JE. Effects of a six-month lifestyle modification intervention on the cardiometabolic risk factors and health-related qualities of life in women with metabolic syndrome. Metabolism. 2010; 59(7): 1,035-1,043.
- Straznicky NE, Grima MT, Lambert EA, Eikelis N, Dawood T, Lambert GW, Nestel PJ, Masuo K, Sari CI, Chopra R, Mariani JA, Schlaich MP. Exercise augments weight loss induced improvement in renal function in obese metabolic syndrome individuals. J Hypertens. 2011; 29(3): 553-564.
- Straznicky NE, Lambert EA, Nestel PJ, McGrane MT, Dawood T, Schlaich MP, Masuo K, Eikelis N, de Courten B, Mariani JA, Esler MD, Socratous F, Chopra R, Sari CI, Paul E, Lambert GW. Sympathetic neural adaptation to hypocaloric diet with or without exercise training in obese metabolic syndrome subjects. Diabetes. 2010; 59(1): 71-79.
- Straznicky NE, Lambert EA, Grima MT, Eikelis N, Nestel PJ, Dawood T, Schlaich MP, Masuo K, Chopra R, Sari CI, Dixon JB, Tilbrook AJ, Lambert GW. The effect of dietary weight loss with or without exercise training on liver enzymes in obese metabolic syndrome subjects. Diabetes Obes Metab. 2012; 14(2): 139-148.
- Yassine HN, Marchetti CM, Krishnan RK, Vrobel TR, Gonzalez F, Kirwan JP. Effects on exercise and caloric restriction on insulin resistance and cardiometabolic risk factors in older obese adults: A randomized clinical trial. J Gerontol A Biol Sci Med Sci. 2009; 64: 90-95.
- Detail
-
Search Plan and Results: PDM: Weight Loss and Metabolic Syndrome 2012
In adults with metabolic syndrome, what is the impact of weight loss (over at least a three-month period) on renal outcomes?-
Conclusion
Two intervention studies regarding the impact of weight loss on renal outcomes reported inconclusive results.
Additional longer-term intervention studies are needed to ascertain an effect of weight loss on renal outcomes in adults with metabolic syndrome with or without meeting the metabolic syndrome criteria for urinary albumin excretion rate or albumin:creatinine ratio.
-
Grade: III
- Grade I means there is Good/Strong evidence supporting the statement;
- Grade II is Fair;
- Grade III is Limited/Weak;
- Grade IV is Expert Opinion Only;
- Grade V is Not Assignable.
- High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
- Moderate (B) means we are moderately confident in the effect estimate;
- Low (C) means our confidence in the effect estimate is limited;
- Very Low (D) means we have very little confidence in the effect estimate.
- Ungraded means a grade is not assignable.
-
Evidence Summary: In adults with metabolic syndrome, what is the impact of weight loss (over at least a 3-month period) on renal outcomes?
- Detail
- Quality Rating Summary
For a summary of the Quality Rating results, click here.
- Worksheets
- Seligman BG, Polanczyk CA, Santos AS, Foppa M, Junges M, Bonzanini L, Nicolaidis G, Carney S, Lopes AL, Sehl P, Duncan BB, Clausell N. Intensive practical lifestyle intervention improves endothelial function in metabolic syndrome independent of weight loss: A randomized controlled trial. Metabolism. 2011; 60(12): 1,736-1,740.
- Straznicky NE, Grima MT, Lambert EA, Eikelis N, Dawood T, Lambert GW, Nestel PJ, Masuo K, Sari CI, Chopra R, Mariani JA, Schlaich MP. Exercise augments weight loss induced improvement in renal function in obese metabolic syndrome individuals. J Hypertens. 2011; 29(3): 553-564.
- Detail
-
Search Plan and Results: PDM: Weight Loss and Metabolic Syndrome 2012
-
Conclusion