VLBW: Pasteurization (2020)

Intervention
In VLBW preterm infants (less than or equal to 1,500g at birth), what is the effect of pasteurization of human milk via enteral nutrition on morbidities and mortality?
- Conclusion
  No studies were identified that evaluated the effect of pasteurization of human milk on morbidities or mortality.
- Grade: V
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Search Plan and Results: VLBW: Pasteurization (2019)
In VLBW preterm infants (less than or equal to 1,500g at birth), what is the effect of pasteurization of human milk on weight and length gain?
- Conclusion
  One study reported potential harm in pasteurization of mother's own milk (MOM) on weight and length gain in very low birth weight (VLBW) preterm infants, however the sample size was very small (N=5), so analysis lacked power.
- Grade: III
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: In VLBW preterm infants (less than or equal to 1,500g at birth), what is the effect of pasteurization of human milk on weight and length gain?
  - Detail
  - Quality Rating Summary
    For a summary of the Quality Rating results, click here.
  - Worksheets
    
    Andersson Y, Sävman K, Bläckberg L, Hernell O. Pasteurization of mother's own milk reduces fat absorption and growth in preterm infants. Acta Paediatrica (Oslo, Norway: 1992). 2007; 96:1,445-1,449.
- Search Plan and Results: VLBW: Pasteurization (2019)
In VLBW preterm infants (less than or equal to 1,500g at birth), what is the effect of pasteurization of human milk on development, gastrointestinal health, bone mineral content, protein utilization or adverse effects?
- Conclusion
  No studies were identified that evaluated the effect of pasteurization of human milk on development, gastrointestinal health, bone mineral content, protein utilization or adverse effects.
- Grade: V
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Search Plan and Results: VLBW: Pasteurization (2019)