VLBW: Type of Protein (2020)

Intervention
In VLBW preterm infants (less than or equal to 1,500g at birth), what is the effect of type of protein on morbidity or mortality?
- Conclusion
  No studies were identified that evaluated the effect of type of protein via enteral nutrition on morbidity or mortality in very low brith weight (VLBW) preterm infants.
- Grade: V
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Search Plan and Results: VLBW: Type of Protein (2019)
In VLBW preterm infants (less than or equal to 1,500g at birth), what is the effect of type of protein via enteral nutrition on weight gain?
- Conclusion
  In two RCTs examining the effect of hydrolyzed protein preterm formula compared to standard preterm formula, results were inconsistent on weight in very low birth weight (VLBW) preterm infants.
- Grade: III
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: In VLBW preterm infants (less than or equal to 1,500g at birth), what is the effect of type of protein via enteral nutrition on weight gain?
- Search Plan and Results: VLBW: Type of Protein (2019)
In VLBW preterm infants (less than or equal to 1,500g at birth), what is the effect of type of protein via enteral nutrition on length and head circumference?
- Conclusion
  One small RCT suggested no significant effect of hydrolyzed protein preterm formula compared to standard preterm formula on infant crown-heel length [MD (95%CI): -1.0 (-4.1, 2.1) cm] or head circumference [-1.0 (-3.9, 1.9) cm] after approximately four months duration.
- Grade: III
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: In VLBW preterm infants (less than or equal to 1,500g at birth), what is the effect of type of protein via enteral nutrition on length and head circumference?
- Search Plan and Results: VLBW: Type of Protein (2019)
In VLBW preterm infants (less than or equal to 1,500g at birth), what is the effect of type of protein via enteral nutrition on feeding tolerance?
- Conclusion
  One RCT determined that infants receiving hydrolyzed protein preterm formula had decreased days from initiation of milk feeds until full milk feeds compared to those receiving standard preterm formula for 28 days.
- Grade: III
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: In VLBW preterm infants (less than or equal to 1,500g at birth), what is the effect of type of protein via enteral nutrition on feeding tolerance?
  - Detail
  - Quality Rating Summary
    For a summary of the Quality Rating results, click here.
  - Worksheets
    
    Mihatsch W, Franz A, Högel J, Pohlandt F. Hydrolyzed protein accelerates feeding advancement in very low birth weight infants. Pediatrics 2002; 110:1199-203
- Search Plan and Results: VLBW: Type of Protein (2019)
In VLBW preterm infants (less than or equal to 1,500g at birth), what is the effect of type of protein via enteral nutrition on protein utilization?
- Conclusion
  One RCT determined that there was no difference in infant nitrogen retention between infants receiving hydrolyzed protein preterm formula compared to standard preterm formula.
- Grade: III
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: In VLBW preterm infants (less than or equal to 1500 grams at birth) what is the effect of type of protein via enteral nutrition on protein utilization?
- Search Plan and Results: VLBW: Type of Protein (2019)
In VLBW preterm infants (less than or equal to 1,500g at birth), what is the effect of type of protein via enteral nutrition on development, bone mineral content, or adverse effects?
- Conclusion
  No studies were identified that evaluated the effect of type of protein via enteral nutrition on development, bone mineral content or adverse effects.
- Grade: V
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.