CKD: Magnesium (2018)

CKD: Magnesium (2018)

• Intervention
  What is the effect of magnesium supplementation on comorbidity outcomes in adults with CKD 1-5D and post-transplant?

  • Conclusion

    Among kidney transplant recipients, magnesium supplementation was associated with lower serum glucose levels but not  Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) in one study. Among hemodialysis patients, magnesium supplementation had no effects on systolic and diastolic blood pressure in one study. Among hemodialysis patients, oral magnesium supplements improved left and right (Constraint Induced Movement Therapy (cIMTs) in one study and the number of patients with improvement in arterial calcifications in another study.

  • Grade: III
    • Grade I means there is Good/Strong evidence supporting the statement;
    • Grade II is Fair;
    • Grade III is Limited/Weak;
    • Grade IV is Expert Opinion Only;
    • Grade V is Not Assignable.
    • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
    • Moderate (B) means we are moderately confident in the effect estimate;
    • Low (C) means our confidence in the effect estimate is limited;
    • Very Low (D) means we have very little confidence in the effect estimate.
    • Ungraded means a grade is not assignable.
  • Evidence Summary: What is the effect of magnesium supplementation on comorbidity outcomes in adults with CKD 1-5D and post-transplant?
    • Detail
    • Quality Rating Summary
      For a summary of the Quality Rating results, click here.
    • Worksheets
      • Turgut F, Kanbay M, Metin M, Uz E, Akcay A, Covic A. Magnesium supplementation helps to improve carotid intima media thickness in patients on hemodialysis. International Urology and Nephrology 2008; 40:1075-82
      • Tzanakis I, Stamataki E, Papadaki A, Giannakis N, Damianakis N, Oreopoulos D. Magnesium retards the progress of the arterial calcifications in hemodialysis patients: a pilot study. International Urology and Nephrology 2014; 46:2199-205
      • Van Laecke S, Nagler E, Taes Y, Van Biesen W, Peeters P, Vanholder R. The effect of magnesium supplements on early post-transplantation glucose metabolism: a randomized controlled trial. Transplant International : official journal of the European Society for Organ Transplantation 2014; 27:895-902
  • Search Plan and Results: CKD: Electrolytes: Magnesium (2018)
     
  What is the effect of magnesium supplementation on magnesium levels in adults with CKD 1-5D and post-transplant?

  • Conclusion

    Oral magnesium supplementation increased serum magnesium levels among hemodialysis patients in two studies, but not among kidney transplant patients in one study.

  • Grade: III
    • Grade I means there is Good/Strong evidence supporting the statement;
    • Grade II is Fair;
    • Grade III is Limited/Weak;
    • Grade IV is Expert Opinion Only;
    • Grade V is Not Assignable.
    • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
    • Moderate (B) means we are moderately confident in the effect estimate;
    • Low (C) means our confidence in the effect estimate is limited;
    • Very Low (D) means we have very little confidence in the effect estimate.
    • Ungraded means a grade is not assignable.
  • Evidence Summary: What is the effect of magnesium supplementation on magnesium levels in adults with CKD 1-5D and post-transplant?
    • Detail
    • Quality Rating Summary
      For a summary of the Quality Rating results, click here.
    • Worksheets
      • Turgut F, Kanbay M, Metin M, Uz E, Akcay A, Covic A. Magnesium supplementation helps to improve carotid intima media thickness in patients on hemodialysis. International Urology and Nephrology 2008; 40:1075-82
      • Tzanakis I, Stamataki E, Papadaki A, Giannakis N, Damianakis N, Oreopoulos D. Magnesium retards the progress of the arterial calcifications in hemodialysis patients: a pilot study. International Urology and Nephrology 2014; 46:2199-205
      • Van Laecke S, Nagler E, Taes Y, Van Biesen W, Peeters P, Vanholder R. The effect of magnesium supplements on early post-transplantation glucose metabolism: a randomized controlled trial. Transplant International : official journal of the European Society for Organ Transplantation 2014; 27:895-902
  • Search Plan and Results: CKD: Electrolytes: Magnesium (2018)