Preterm Infant (VLBW) Enteral Nutrition Systematic Review (2017-2020)

Preterm Infant (VLBW) Enteral Nutrition Systematic Review (2017-2020)

Very Low Birthweight Preterm Term Infants Enteral Nutrition Systematic Review
The expert workgroup focused on very low preterm term infants (≤1,500 grams birth weight) and on these sub-topic areas:

• Macronutrients
  • Breast Milk Fortifier Type
  • Breast Milk Fortifiers
  • Formula Enrichment
  • Pasteurization
  • Protein Amount
  • Protein-Energy
  • Type of Fat
  • Type of Protein
  • Non-Protein Energy
• Human Milk vs. Formula
  • Mothers’ Milk vs. Exclusive Formula
  • Mothers' Milk Dose Response
  • Supplementation of Mothers’ Milk with Donor Milk
  • Human Milk (Mothers’ Milk and Donor) vs. Exclusive Formula
  • Human Milk (Mother’s milk and Donor) Dose Response
  • Donor Milk vs. Exclusive Formula

Key Findings:

• Infants fed human milk should be enriched with multi-nutrient fortifiers
• Infants should be fed with 3.5-4.0 g protein/kg/day
• Evidence is lacking that supplementation with omega 3 fatty acid influences health outcomes
• Infants fed ≥75% mothers’ own milk compared to formula is associated with lower incidence of retinopathy of prematurity
• There is evidence of a positive dose response relationship between mothers’ own milk and development, a negative dose response between mothers’ own milk and sepsis
• When mothers’ own milk is lacking infants should be provided with pasteurized donor milk

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